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Professor Dame Pamela Shaw
Professor Dame Pamela Shaw

World-renowned MND researcher and clinician says making research easier to understand, and showing why it matters, is vital

One of the world’s leading scientists on motor neurone disease (MND) and other neurological diseases says making complex research more accessible and understandable is vital to show progress is being made at developing treatments for the conditions.
DNA strand

FDA approves trial to advance pioneering treatment for Hereditary Spastic Paraplegia (HSP)

The US Food and Drug Administation (FDA) has approved BlackfinBio Limited’s Phase 1/2 clinical trial for its novel adeno-associated virus (AAV) gene therapy targeting Hereditary Spastic Paraplegia (HSP) Type 47 (SPG47).
DNA strands

Sheffield spinout takes major step towards advancing pioneering treatments for Hereditary Spastic Paraplegia (HSP)

BlackfinBio Limited is a spinout company from the University of Sheffield set to pioneer novel therapies for rare genetic neurological diseases.

Image of motor neurones

Groundbreaking EXPERTS-ALS study for MND treatments

The EXPErimental medicine Route To Success in ALS (EXPERTS-ALS) project aims to rapidly screen potential drugs for evidence that they can slow down damage to the nervous system occurring in people with motor neuron disease
Professor Mimoun Azzouz holding a petri dish

Comment: Turning the biggest disappointment of a career into a new era for UK gene therapy manufacturing

Professor Mimoun Azzouz discusses career challenges before opening the Gene Therapy Innovation and Manufacturing Centre (GTIMC) at the University of Sheffield.
Medical illustration of a brain with stroke symptoms

Our 2024 research highlights

As the year comes to a close, we want to take a moment to reflect on and celebrate some of our research news stories from 2024.
woman using laptop on knee

People living with MND given a voice in research with new digital tool

People living with motor neuron disease (MND) will have more opportunities to participate in groundbreaking research, thanks to a new digital platform designed to accelerate the search for a cure for the debilitating disease.

Chess board with two chess pieces

Analysing the roles of nature and nurture in a chess prodigy

For parents and families thinking about supporting their children in adopting new skills, Dr Nemanja Vaci's findings can help them to seek the best approaches.
close up image of mitochondria in fibroblasts

World Alzheimer’s Month - Understanding the mitochondria

As part of World Alzheimer’s Month, we’re shining a light on the Mortiboys Lab, a lab dedicated to understanding the mitochondria in neurodegenerative diseases.